N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺
FK 3311(FK 3311)
CAS: 116686-15-8
化学式: C15H13F2NO4S
| 中文名 | FK 3311 |
| 英文名 | FK 3311 |
| 别名 | 化合物FK 3311 N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺 |
| 英文别名 | FK-3311 FK3311 FK 3311 CS-1073 COX-2 Inhibitor V COX-2 Inhibitor V, FK3311 N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]- N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]-methanesulfonamide FK3311 |
| CAS | 116686-15-8 |
| 化学式 | C15H13F2NO4S |
| 分子量 | 341.33 |
| 密度 | 1.419±0.06 g/cm3(Predicted) |
| 沸点 | 431.3±55.0 °C(Predicted) |
| 溶解度 | 10毫米DMSO |
| 酸度系数 | 6.82±0.10(Predicted) |
| 存储条件 | Store at RT |
| 外观 | 白色固体 |
| 体外研究 | Cyclooxygenase (COX) is an intracellular enzyme that converts arachidonic acid into prostaglandin (PG)G2 and PGH2. The racemic mixtures and the (R)- and (S)-isomers of the 2 metabolites were inactive in the PGE2 test. IC50 values were more than 100 uM for (2 and 5), compared to 1.6 uM for FK 3311 (COX-2 Inhibitor V). Antiinflammatory activity was assessed by inhibition of adjuvant-induced arthritis, and analgesic activity was determined in the acetic acid-induced writhing assay. Following p.o. administration of 10 mg/kg, racemic (2) and its optical isomers showed activity comparable to FK-3311 (76% inhibition) in the adjuvant arthritis test, whereas racemic (5) showed very weak activity, and (R)- and (S)-(5) were not tested. With regard to analgesic effects, FK-3311 and racemic (2) showed 81 and 62% inhibitions, respectively, at a dose of 100 mg/kg p.o. The (R)- and (S)-isomers of (2) and racemic (5) all showed 46% inhibition of writhing syndrome. (R)- and (S)-(5) were less active showing 16 and 20% inhibitions, respectively. |
| 体内研究 | L-PVR, CO, PaO(2), and WDR were significantly better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly reduced in the FK group compared to the control group. The serum TxB(2) levels were significantly lower in the FK group than in the control group, while 6-keto-PGF(1alpha) levels were not significantly reduced. Two-day survival rate was significantly better in the FK group than in the control group. Survival rate was significantly better and serum GOT levels 30 min after reperfusion were significantly lower in the FK high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control. |
N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.93 ml | 14.649 ml | 29.297 ml |
| 5 mM | 0.586 ml | 2.93 ml | 5.859 ml |
| 10 mM | 0.293 ml | 1.465 ml | 2.93 ml |
| 5 mM | 0.059 ml | 0.293 ml | 0.586 ml |
最后更新：2024-01-02 23:10:35
N-[4-乙酰基-2-(2,4-二氟苯氧基)苯基]-甲烷磺酰胺 - 简介
FK 3311是一种有机化合物，化学名为1-氟丁烷。以下是关于FK 3311的性质、用途、制法和安全信息的介绍：
性质：
FK 3311是一种无色液体，在常温下有刺激性气味。它是可燃物质，可以溶解于许多有机溶剂中。
用途：
FK 3311在工业和实验室中有多种应用。它可用作有机合成中的试剂，用于合成其他有机化合物。FK 3311还可用于制备特殊涂层和聚合物材料。
制法：
FK 3311的合成通常通过将丁烯与氢氟酸反应而得到。
安全信息：
FK 3311具有一定的安全风险。它是一种易燃液体，应严格避免与火源接触。在使用或操作FK 3311时务必佩戴个人防护装备，如防护眼镜、手套和防护衣。在储存FK 3311时，应将其保存在密封的容器中，并放置在通风良好的地方，远离火源和热源。如果误食或误吸入FK 3311，应立即就医。在使用前，务必仔细阅读和遵守相关安全数据表和操作说明。
性质：
FK 3311是一种无色液体，在常温下有刺激性气味。它是可燃物质，可以溶解于许多有机溶剂中。
用途：
FK 3311在工业和实验室中有多种应用。它可用作有机合成中的试剂，用于合成其他有机化合物。FK 3311还可用于制备特殊涂层和聚合物材料。
制法：
FK 3311的合成通常通过将丁烯与氢氟酸反应而得到。
安全信息：
FK 3311具有一定的安全风险。它是一种易燃液体，应严格避免与火源接触。在使用或操作FK 3311时务必佩戴个人防护装备，如防护眼镜、手套和防护衣。在储存FK 3311时，应将其保存在密封的容器中，并放置在通风良好的地方，远离火源和热源。如果误食或误吸入FK 3311，应立即就医。在使用前，务必仔细阅读和遵守相关安全数据表和操作说明。
最后更新：2024-04-09 20:52:54
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